Higher levels of melanin result in darker skin tones
Analysis of single-cell RNA sequencing Single-cell RNA sequencing (scRNA-seq) data (HRA000425) were downloaded from Genome Sequence Archive (SRA)-Human databases in China National Center for Bioinformation 16 , converted into FASTQ format using fasterq-dump software (sratoolkit 3.0.2, NCBI, NIH, Bethesda, MD, USA), converted into a matrix data file using Cell Ranger software version 3.0.2 (10xGenomics, Pleasanton, CA, USA), converted into Seurat objects using Seurat 5.0.1 software (Satija lab, Lower Manhattan, New York, NY, USA), and plotted for t -distributed stochastic neighbor embedding ( t -SNE) visualization
For intramuscular, intravenous or subcutaneous injection
This contributes to the occurrence of l-dopa-related complications (LDRCs), notably motor fluctuations and l-dopa-induced dyskinesia, whose severity is associated with nigral denervation 2,3,4,5,6,7,8,9