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When to increase dose Consider increasing if: Minimal response after 4-6 weeks at current dose No side effects at current dose Current dose below the higher end of recommended range Goals not being met with conservative approach Increase gradually, typically by 25-50% at a time

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You have three administration options: Option A: Injectable GHK-Cu only 200 to 600 mcg per day, subcutaneous Best for systemic tissue support (skin, joints, hair, internal tissues) No fasting required Option B: Topical GHK-Cu only Applied to target areas once or twice daily Best for localized skin concerns (face, abdomen, specific areas of laxity) Lower cost, no injection required Option C: Injectable plus topical (recommended for maximum benefit) Injectable for systemic support plus topical for targeted skin areas Most thorough approach Addresses both internal tissue health and external skin quality Step 4: Improve and Maintain As semaglutide is titrated up over the following months, continue GHK-Cu consistently