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It appears in human plasma at approximately 200 ng/ml in young subjects, with a drop of more than 60 % between ages 20 and 60, an observation that motivated forty years of research on its role in tissue repair, wound healing, hair growth and cutaneous longevity

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Compared with surgery, chemotherapy, and other anticancer means, PDT has multiple advantages such as non-invasiveness, negligible drug resistance, and spatial selectivity

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