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When GIPRAs and GLP-1RAs were co-administered to obese mice, the combination significantly enhanced both appetite suppression and weight loss compared to monotherapy [33, 34]
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In comparison with naturally occurring receptor ligands, retatrutide has lower potency at the human glucagon and GLP-1 receptors, at approximately 0.3- and 0.4-fold, respectively, while showing markedly greater potency at the human GIP receptor, at about 8.9-fold
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