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Kampala, UG
The addition of metabolic biomarkers improved the predictive ability of models using IMPACT and CRASH parameters to estimate severity/prognosis [18, 30, 31]
Simultaneously, ROS activate PKC isoforms and the AGE-RAGE signaling cascade, which upregulate pro-inflammatory cytokines (TNF-, IL-6) and adhesion molecules (VCAM-1, ICAM-1) through NF-B activation (Gonzlez et al., 2023)
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