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However, there are not enough clinical trials to determine the potential therapeutic mechanism responsible

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Differential expression and release of cytokines by an in vitro reconstructed human epidermis following exposure to skin irritant and sensitizing chemicals

Moreover, this system exhibits pronounced cell-type specificity: meiotic germ cells are far less tolerant to heat than Sertoli cells and are more prone to apoptosis (Shahat et al., 2020)