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adverse event reports 432 involved AKI, accounting for 0.47% of cases Ozempic and Wegovy (semaglutide): 41,065 total U.S

Thereafter, follow-up visit frequency may be reduced to every 6 months for long-term management

note that lactulose is not recommended as it may worsen bloating [14] [18] For abdominal pain : Antispasmodics (mebeverine, peppermint oil) taken before meals For global symptoms : Tricyclic antidepressants at low doses, with selective serotonin reuptake inhibitors (SSRIs) considered if TCAs are ineffective or not tolerated Psychological therapies have robust evidence in IBS management, including cognitive behavioural therapy (CBT), gut-directed hypnotherapy, and mindfulness-based interventions

Although direct effects of GLP-1 RAs on the GBM have not been fully elucidated, their anti-inflammatory, anti-fibrotic, and antioxidative properties may indirectly support GBM integrity