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TRAF3IP2 (TRAF3 interacting protein2) TRAF3IP2 is a key regulator of the immune and inflammatory response and exerts multiple effects to promote CV stiffening, inflammation, and fibrosis that contribute to cardiac dysfunction and vascular inflammation

This effect results from delayed gastric emptying and central nervous system effects on appetite regulation centres

If only larger vials are available, some researchers reconstitute (for lyophilized) or draw multiple doses in advance and store pre-loaded syringes separately

Imaging studies such as plain radiographs, ultrasound, or MRI may be indicated to assess for structural joint abnormalities, inflammatory changes, or other pathology