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The proportions of gastrointestinal (GI) SAEs were comparable or lower in the low eGFR subgroups compared with the highest eGFR subgroup in our analysis, suggesting that the greater BW reduction observed in the low eGFR subgroups is probably not related to GI SAEs

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In practice, that often means: Your provider may be comfortable starting a standard daily vitamin D supplement without ordering labs first if: You are generally healthy You are taking a modest daily dose in the typical range You do not have bone disease or other conditions that raise concern Your provider is more likely to want vitamin D blood work if: You have a history of osteoporosis or frequent fractures You have conditions that affect vitamin absorption You are on medicines that change vitamin D or calcium metabolism You are considering higher dose or long term vitamin D plans beyond typical daily intake Vitamin B12 Vitamin B12 is crucial for red blood cell formation, nerve health and DNA production

It is not intended for use in humans or animals