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Diabetic Retinopathy Complications: Has been reported in a cardiovascular outcomes trial with semaglutide injection
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The signaling peptide is cleaved, leaving behind a human GLP-1R protein containing the C-terminal FLAG epitope (green residues)
Some studies suggest that variations in GLP-1 receptor genes and other metabolic pathways might affect how individuals respond to these medications, but there is currently no role for routine genetic testing to predict response
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