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3.2 Therapeutic potential in obesity Although the incretin effects of GIPR undoubtedly play a crucial role in preventing postprandial glucose excursion, there is still intensive debate on whether the GIPR should be activated or inhibited for the treatment of obesity
By blocking IR/IGFR signal pathway, the motility and metastases of cancer cells were significantly inhibited (Wang et al., 2019)
It gives Novo Nordisk an opportunity to remain competitive on efficacy while it continues developing next-generation therapies. Other drugs have already shown greater efficacy in prior studies, and the broader GLP-1 space is likely to see much more significant change as new molecules enter the market. Balazs called the higher dosage a major jump, noting that the incidences of stomach- and skin-related side effects at this higher dose are meaningful. This approval is for obesity management, not diabetes treatment, the expert emphasized
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