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10.1111/j.1442-200X.2010.03310.x 14 BrandalizeA
Lancet 402 , 429431 (2023)
The key role of the WNT/-catenin pathway in metabolic reprogramming in cancers under normoxic conditions
Of particular relevance to IGF-1 anabolic research are TSC2 (relieving inhibition of mTORC1, driving protein synthesis) and FoxO transcription factors (inhibiting their nuclear translocation, blocking expression of atrogenes like MuRF1 and atrogin-1 that drive muscle protein breakdown)
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