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Like liraglutide, semaglutide incorporates an Aib substitution at the 8th position in place of Ala, which confers resistance to enzymatic degradation by DPP-4
Many patients experience reduced hunger, early fullness, and gastrointestinal side effects that require thoughtful meal planning
Heliyon 9 , e18137 (2023)
Despite demonstrating efficacy in reversing MASH, maintaining life-style changes over the long term is challenging for most patients, and there are currently no pharmacological treatments approved [4]
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