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These include: Those with a history of cancer: IGF-1 can be involved in the growth of certain types of cancer
The Journal of endocrinology , 165 (3), 569577.
A structure-based assignment of the glutathione activator site without transition-state analogues is much more difficult because of labile GSH interactions 2 that likely depend not only on the presence of the first glutathione moiety but also on conformational changes of the glutathionylated enzyme 3,12,37,44
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