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Additionally, RcGPX4 depended on the MAPK3-ICE1-C-repeat-binding factor (CBF)-COR signal transduction pathway and ABA-dependent pathway to negatively regulate the freezing tolerance of transgenic plants
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But the full effects usually take a bit longer to show up
10 In the study by Jung et al, 11 no adverse effects were reported after 12 weeks of use among the 24 participants
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