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2 It is also an increasing global health burden, with 578 million people (10.2%) estimated to meet diagnostic criteria by 2030 and 700 million (10.9%) by 2045

The "Safety Ceiling": Because Tesamorelin relies on the pituitary's own capacity, the trials did not observe the "runaway" IGF-1 levels sometimes seen with high-dose synthetic GH, reinforcing its profile as a more controlled therapeutic option

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