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Description

In this pathway, Chemerin exerts a bidirectional regulatory effect: it can exert an anti-inflammatory effect by inhibiting the nuclear translocation of the p65 subunit, likely the effect exerted by its isoform C15, and can also activate NF-B through the reactive oxygen species (ROS)-silent information regulator 1 (Sirt1) pathway to promote the inflammatory response (Jaworek et al., 2019)