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For semaglutide, discontinuation is required at least 2 months before a planned pregnancy as a result of its long half-life

(2) Premixed insulin 2-3 times a day (premixed human insulin 2 times/day and premixed insulin analog 2-3 times/day): adjust the insulin dosage according to the blood glucose level before bedtime and three meals, and adjust the dosage once every 3-5 days until the blood glucose reaches the standard[1]