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High-throughput methods to assess drug radioprotection In prior studies 17 , immunohistochemical (IHC) staining was used to quantify the number H2AX and 53BP1 puncta within nuclei, which are sensitive markers for double-strand breaks 50 and, thus, direct measures of radiation damage/protection
Preclinical evidence Peripheral or systemic dosing of L-theanine engages brain targets, modulates monoaminergic and glutamatergic signaling, and enhances synaptic plasticity
In: UpToDate Basow, DS (Ed), Waltham, MA
Both achieve the fundamental goal of stimulating natural GH production
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