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The progressive degeneration of neuronal cells that accompanies the decline of memory and other cognitive functions in subjects with Alzheimers disease is associated with an intracellular aggregation of Tau fibrils, an extra-neuronal accumulation of b-amyloid peptides into senile plaques, and an oxidation-reduction (redox) imbalance of complex etiology

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All available safety data including information on skin sensitivity derives from clinical trial publications, conference presentations, and investigator reports, rather than from a formally approved regulatory dossier