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Researchers who evaluate their protocol at week 8 are seeing titration-phase results, not maintenance-phase results
Isolated T cells were activated with human T activator CD3/CD28 Dynabeads (Life Technologies, 11131D) at a 1:1 cell-to-bead ratio for 24 h before transduction
This is where further workup becomes important
In one study from Israel, researchers compared this standard schedule with a slower increase that took 16 weeks to reach a 1 mg dose
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