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There are two deadly obstacles that all people with type 1 diabetes constantly need to navigate around: The threats of severe low blood sugar (hypoglycemia) and diabetic ketoacidosis (DKA)
[3] Weight loss typically follows a predictable pattern: Initial phase (0-3 months): Gradual dose escalation with modest weight reduction as appetite suppression begins Active loss phase (3-12 months): Most significant weight reduction occurs during this period Plateau phase (12+ months): Weight stabilises
Among the patients who developed gastrointestinal side effects, the number of gut bacteria such as Sutterella , Allisonella , Akkermansia , Bacteroides , and Paraprevotella species was significantly elevated (Bryrup et al., 2019), which may be a possible cause of gastrointestinal discomfort reactions in some patients
Concomitant use of weight-promoting medications, such as insulin or sulfonylureas, may further blunt the weight loss effects of GLP-1 RAs [45]
