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[ 12 , 16 ] Researchers hypothesize that this mechanism could contribute to some of the sleep-related effects reported in early studies
However, as a macromolecular polysaccharide, the bioavailability of APS is extremely low, the oral absorption efficiency and its specific form in vivo are still unclear, and the current mechanism is not deep enough, lack of loss-of-function validation, and its purity and homogeneity also pose a challenge to the assessment of pharmacological effects
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Caroni P, Chowdhury A, Lahr M (2014) Synapse rearrangements upon learning: from divergent-sparse connectivity to dedicated sub-circuits
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