Abbreviations GLP-1RAs: Glucagon-like peptide 1 receptor agonists GLP-1: Glucagon-like peptide 1 ADRs: Adverse drug reactions SSIBs: Suicidal or self-injurious behaviors EMA: European Medicines Agency FDA: The Food and Drug Administration FAERS: The Food and Drug Administration Adverse Event Reporting System MedDRA: The Medical Dictionary for Regulatory Activities TTO: Time-to-onset CI: Confidence interval IC: Information Component References Lingvay I, Leiter LA
GLP-1 receptors sit throughout the body, in the brain, pancreas, heart, and blood vessels, and the drugs appear to reduce inflammation and the organ-damaging fat that drives much metabolic harm
Secondary outcomes were cardiometabolic risk factors (e.g., fasting glucose, total cholesterol, high-density lipoprotein, systolic blood pressure, triglycerides, and waist circumference) and adverse effects
Together, they create a dynamic duo that promotes optimal health, providing comprehensive protection against cellular damage and supporting overall immune resilience