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These gene products are responsible for a wide range of antioxidant, anti-inflammatory, cytoprotective, and detoxification functions and include catalase, superoxide dismutase (SOD)-3, heme oxygenase-1, glutathione-S-transferases, NAD(P)H-quinone oxidoreductase (NQO1), glutathione peroxidase, and glucuronosyltransferase-1a6 (UGT-1a6) [11]
The nonclinical and clinical studies reported to date indicate that they could be predictive of the severity of APAP-induced injury, especially when measured in conjunction with other transcriptomics and proteomics biomarkers as well as the standard parameters
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