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Gonzalez D, Narasimman M, Best JC, Ory J, Ramasamy R
Supplemental creatine may reduce the need to manufacture creatine from SAM, conserving methyl groups and reducing SAH generation from endogenous creatine synthesis
Limitations include limited large-scale human clinical evidence, challenges in extrapolating in-vitro concentrations to in-vivo contexts, stability sensitivities (light, heat, alkaline pH), and variability in supplier purity
Do lipotropics need to be refrigerated
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