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Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial. Nat Med 28, 20832091 (2022)
GLP-1s: Lower blood sugar Reduce appetiteso you eat less and feel fuller Promote healthy weight loss Improve metabolism Lower whole-body inflammationincluding that which affects your joints GLP-1s Target Both Metabolic and Inflammatory Pathways Recent research shows that GLP-1 medications can: Lower levels of inflammatory cytokines like TNF-alpha, IL-6, and IL-1 Restore a healthier gut microbiome and calm immune reactions Reduce fat-driven inflammationwhy losing just 510% of body weight improves autoimmune diseases Reverse insulin resistancea key link between metabolic and autoimmune disease Reduce oxidative stress, protecting organs and joint cartilage GLP-1s in RA, PsA, OA, and More: Evidence and Results Rheumatoid Arthritis Obesity increases RA risk and severity
Many patients report subjective improvements in energy levels after initiating GLP-1 therapy, though this effect is not universal and reflects multiple contributing factors rather than direct pharmacological stimulation
Rao S, Singh S
