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Adding untested ingredients, such as Vitamin B12, to compounded GLP-1s introduces significant risks without proven benefit: No clinical trials support the safety or efficacy of these combinations
This led to further investigations and the eventual development of bremelanotide, a related compound used to treat sexual dysfunction
That said, the animal research reveals several noteworthy cardiovascular effects
Tirzepatide is administered subcutaneously, but the inflammatory response can extend into underlying muscle tissue, particularly if the injection is deeper than intended or if there is individual susceptibility to inflammatory reactions
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