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The damage caused by SAP to the vascular endothelium is manifested as the release of inflammatory mediators and leukocyte adhesion, increased vascular permeability, changes in blood flow shear stress, microthrombosis, and microcirculatory disorders
Thus, both CI and CII exhibited a significant lower activity, which was confirmed by a lower state apparent upon Gclc ablation (Supplementary Fig
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Patients taking the drugs were also more likely to have nausea, vomiting or gastroesophageal reflux disease (GERD)
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