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Eligibility varies by trial: The obesity arm typically required a BMI of 30 or higher (or 27 with a comorbidity)
Metformin in turn has the potential to inhibit the expression of the aromatase enzyme, decreasing estrogen production
Plans may exclude specific diseases, treatments, or drugs only if the exclusion applies uniformly to all similarly situated individuals and does not target those with a particular condition
Continuing to train at pre-escalation intensity during this window is a recipe for missed workouts, poor performance, and frustration
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