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The pituitary receptor system does not desensitize with CJC-1295/Ipamorelin at standard clinical doses the way it does with direct GHRH or older GHRPs, which is one of the reasons it became the preferred combination in supervised practice
The combination of GLP-1R agonists with each other has not been studied previously, suggesting that due to their similar mode of action, there would not be an enhancement in therapy from this combination
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