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Comparative work with tirzepatide further isolates the specific contribution of glucagon receptor agonism to the overall pharmacological profile

- acetylcholine will produce a dose-dependent changes of blood pressure & heart rate (Figure 1)(Vanderah, 2024): : Low-dose intravenous acetylcholine Primarily activates muscarinic (M3) receptors on vascular endothelial cells (Gericke et al, 2011)