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This clinical observation is possibly because the methylcobalamin delivered by this method is better absorbed into the bloodstream, or it is more bio-available, or the effect is more noticeable because of the constantly higher blood level

Studies have reported low serum folate levels in 15% to 38% of patients with depression and in at least 56% of patients with affective disorders (65)

Evidence of the switch to the production of QA can also be seen in the rapid increase in the QA:KA ratio as glutaric acid rises and the almost total absence of 5HIAA as the QA:KA ratio rises

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