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Indeed, humans with homozygous loss-of-function mutations in the ANGPTL3 gene have low serum levels of not only triglycerides and apo-B-containing lipoproteins (VLDL/LDL) but also low levels of apoA-I lipoproteins (HDL)

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Three individuals (each with a non-synonymous SNP) are heterozygous at these loci, and originated from Sub-Saharan Africa ( C329T ), India-Pakistan ( G571A ), and Japan ( G1520A ) (Xu et al., 2005)