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Dysfunction within the CNS Brain imaging studies have demonstrated an association between PDPN and structural changes in key somatosensory regions, such as the thalamus and somatosensory cortex, and altered functional connectivity within ascending pain pathways and cortical regions involved in pain processing
[4] C terminal domain structure [edit] The C-terminal domains contains two alpha-helices and four beta-strands
The 2.02% average A1C reduction observed in diabetic trial participants at 48 weeks represents the culmination of progressive improvement throughout the study period
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