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confirmed that TFAP2C regulated GPx1 expression by directly binding to the GPx1 promoter, which contains an AP-2 regulatory region, and the methylation of the CpG island in the GPx1 promoter region prevented the binding of TFAP2C by encompassing the AP-2 regulatory region [81]
The study met its primary endpoint of demonstrating non-inferiority vs Gla-100 change in HbA1c from baseline at week 26
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