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This 28day guideline comes from the USP Compounding Standards, which sets standards for sterile compounding and states that an opened multidose vial with antimicrobial preservative should be discarded within 28 days unless the manufacturer specifies otherwise

If persistent beyond 2 weeks, show your doctor

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Forty animals with fasting blood glucose higher than 11.1 mmol/L and body weight ranging from 28.9 to 36.0 g were randomly divided into control group, MET group (0.26 g/kg), low-dose DTE group (DTE-L, 0.78 g/kg) and high-dose DTE group (DTE-H, 1.56 g/kg), with 10 animals in each group