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Occasional reports mention mild gastrointestinal effects including nausea or changes in appetite

B12 deficiency can give rise to numerous health issues, from persistent fatigue to more severe problems such as cognitive complications

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But that peripheral-only action means it does not suppress appetite, does not change energy expenditure through central pathways, and does not produce the dramatic caloric deficits that GLP-1 agonists like semaglutide or tirzepatide create