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[59] Overall, six months after the therapy, bupropion increases the likelihood of quitting smoking approximately 1 } : CS1 maint: DOI inactive as of March 2026 (link) European Journal of Pharmacology
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However, both compounds individually cause: Nausea (60-80% of users at higher doses) Vomiting (20-35%) Diarrhea (25-40%) Injection site reactions (15-25%) Potential pancreatitis (rare but serious) Combining these compounds could theoretically amplify these effects, though the actual incidence and severity remain unstudied
Metformin may be tried first due to its lower cost and established safety profile
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