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In addition, Lactobacillus rhamnosus GG (129) strengthened bone microstructure and bone biomechanics by adjusting the ratio of Firmicutes/Bacteroidetes, maintaining Th17/Treg balance, repairing mucosal damage caused by estrogen deficiency, and upregulating the levels of GLP-2R, CTX, P1NP, and RANKL

these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor

While medications can be helpful tools, they often require ongoing use to maintain results