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Due to this high aerobic demand, the generation of high amounts of ROS and other oxidative by-products is unavoidable ( GSH is synthesized via two ATP-dependent enzymatic steps catalyzed by glutamate-cysteine ligase (GCL) and glutathione synthetase
Given the relatively older population (median age 69 years), non-cardiovascular mortality over the 4.5-year follow-up period may reduce the number of individuals at risk for cardiovascular events, potentially leading to modest overestimation of projected event rates
We previously demonstrated a similar expression pattern between rodents and non-human primates (86)
NKF 2013a
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