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Your prescriber may recommend a dose reduction rather than stopping entirely

Understanding your peptide genetic profile alongside your cardiovascular biomarkers can support a more personalized discussion with your provider about GLP-1 eligibility, expected benefits, monitoring frequency, and whether compounded GLP-1 options (semaglutide or tirzepatide) align with your individual health trajectory

To interrogate the reliability of our findings, we performed western blot analysis in a separate CSDS cohort for the only protein affected in all three brain regions and the top affected protein in the NAc, RPRD2 (regulation of nuclear pre-mRNA domain containing 2), which plays an important role in gene transcription and was predicted to be elevated in resilient animals relative to susceptible in the NAc