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The disruption of the ubiquitination of NRF2 allows the escape from the proteasomal degradation, activating the NRF2 transcriptional program (Dinkova-Kostova et al
Proc Natl Acad Sci U S A (2003) 100(11):682530.10.1073/pnas.0631828100 56 YanSMarguetDDobersJReutterWFanH
Numerous studies have demonstrated that for every 10% increase in body mass index (BMI), the risk of developing OSAS increases by nearly six-fold (7, 8)
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