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Upregulation of TXNIP by ROS stimulated the NLRP3 inflammasome, which activated the protease caspase-1 to facilitate the release of inflammatory cytokines such as interleukin-18 (IL-18) and interleukin-1 (IL-1) and triggered inflammatory responses
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Some patients may require more frequent administration, but this should only be adjusted under clinical supervision after excluding other causes of persistent symptoms
Supplementary figure C shows the cumulative incidence curves for serious renal events, with a lower cumulative incidence for the GLP-1 receptor agonist-SGLT-2 inhibitor combination and the curves diverging after nine months of use
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