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(2018) systematically reviewed the association between SSRI use in early pregnancy and the risk of fetal congenital malformations by searching for relevant studies in the PubMed, Embase, Web of Science, and Cochrane Library databases

However, after identifying that both of these women carried an MTHFR gene variation, and introducing a supplement that contains the methylated form of folate, zinc, vitamin B3, vitamin B6, vitamin B12, and cobalamin, both women were able to conceive and give birth to healthy babies

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