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Treatment considerations include: Concurrent folate supplementation if deficient (never give folate alone, as it may precipitate neurological deterioration) Potassium monitoring during initial treatment in severe anaemia or at-risk patients (e.g., those with heart failure) Response assessment: reticulocyte count peaks at 57 days, haemoglobin normalises within 68 weeks Neurological symptoms may take 612 months to improve and may not fully resolve Patients should be advised that treatment for pernicious anaemia or post-surgical deficiency is lifelong
The catch is that the effect requires consistent, high-dose exposure, fades when treatment stops, and works very unevenly between individuals
However, further vitro testing is needed to fully understand its therapeutic applications and efficacy
Vniant MM, Lu SC, Atangan L, et al
