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It produces beneficial effects if administered for short periods, because raising peripheral insulin levels acutely increases insulin levels in the brain and cerebrospinal fluid (CSF) (1719)
Recent research indicates that bile acids play a significant role in improving overall metabolism and promoting weight loss following bariatric surgery by activating signaling pathways involving the farnesoid X receptor (FXR) and the G protein-coupled bile acid receptor (TGR5) [59]
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