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RA patients commonly present with elevated iron metabolism indicators like serum iron and ferritin, and the concentration of iron is positively correlated with the severity of joint inflammation ( 4.2 Lipid peroxidation and oxidative stress in RA Oxidative stress as a major pathogenic hallmark of RA promotes the local microenvironment at the RA lesion sites, enhances abnormal synoviocytes proliferation, and exacerbates inflammatory infiltration ( In RA, excessive ROS accumulation and sustained inflammatory activation promote synovial, vascular, and joint damage