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Early micronutrient supplementation protects against early stress-induced cognitive impairments
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Comprehensive in vivo safety evaluation including hemolysis testing, blood biochemistry, body weight monitoring and histopathological examination of major organs showed no significant toxicity, while pharmacokinetic profiling revealed prolonged circulation half-life and enhanced bioavailability compared with free doxorubicin, confirming that the folate-targeted chitosanMOF platform successfully translated high drug loading, receptor-specific uptake and controlled release into improved therapeutic performance with acceptable safety margins [115]
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