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FIGURE 3 3.3 Impact of linezolid and/or vitamin C on serum lactic acid, Beclin-1, and inflammatory parameters, TNF-, and IL1 As shown in Figure 4, linezolid induced a significant elevation of serum lactic acid level (p 0.05) to approximately 5-fold (6.090 0.220 mmol/L) compared to the non-treated control group (1.168 0.125 mmol/L), accompanied by significant increase of inflammatory mediators both TNF- to approximately 3-fold and IL1 to approximately 4-fold (142.9 7.678 pg/mL and 147.0 6.602 pg/mL, respectively) versus controls (42.45 2.928 pg/mL and 37.73 2.193 pg/mL, respectively)
Low cellular uptake: Even if some glutathione reaches the blood, it may not effectively cross the cell membrane where it is needed most
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